Direct Detection of Diverse Metabolic Changes in Virally Transformed and Tax-Expressing Cells by Mass Spectrometry

P. Sripadi, B. Shrestha, R. L. Easley, L. Carpio, K. Kehn-Hall, S. Chevalier, R. Mahieux, F. Kashanchi, A. Vertes

PLoS One, 2010, 5, e12590
DOI: 110.1371/journal.pone.0012590 | Impact factor (2011):

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SUMMARY

Viral transformation of a cell starts at the genetic level, followed by changes in the proteome and the metabolome of the host. There is limited information on the broad metabolic changes in HTLV transformed cells.